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Applied DNA Sciences Inc. APDN, 29.82% (“Applied DNA” or the “Company”) a baton in Polymerase Alternation Reaction (PCR)-based DNA accomplishment for artefact authenticity, traceability solutions, nucleic acid-based biotherapeutic development, and aqueous biopsies for blight diagnostics, and Takis Biotech (“Takis”), a aggregation focused on the development of blight vaccines, and founded by scientists from Merck Assay Laboratories, appear today that the architecture of 4 DNA vaccine candidates will be produced for preclinical beastly testing via the Company’s proprietary PCR-based DNA (“LinearDNA”) accomplishment systems.

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The companies’ advertisement follows their account on February 7, 2020 announcement an broadcast Joint Development Agreement (JDA) amid the Company’s majority-owned subsidiary, LineaRx, Inc. and Takis Biotech to board the preclinical development of a PCR-produced LinearDNA vaccine adjoin COVID-19.

“Since accretion our JDA to board the following of a COVID-19 vaccine, the virus has appeared on about every continent. We apprehend commitment of the 4 preclinical vaccine candidates from Takis in this month. Aural weeks of accession we apprehend to anon calibration up PCR-based assembly of anniversary vaccine applicant and address them aback to Takis who will actuate anniversary vaccine’s about abilities to abet an allowed acknowledgment in vaccinated mice,” declared Dr. James A. Hayward, admiral and CEO of Applied DNA and LineaRx.

The two firms accept advised 4 preclinical vaccines on the base of the “Spike” protein anatomy (the proteins amenable for the “crown” on the virus surface, and from beginning its name derives). It is the Fasten protein that enables uptake of the coronavirus, by bounden to specific receptors on the host cells. One of the 4 applicant vaccines is the absolute fasten gene; the actual 3 are variants based aloft epitope mapping (identifying the acceptable antigenic portions of the protein) and accumulating the agnate genitalia of the ‘S’ gene into a new constructed LinearDNA gene, and codon access (to ensure the new LinearDNA vaccine genes are calmly bidding as proteins, already the genes accept been delivered to a baby allotment of the nuclei of the patient’s beef cells.) Additionally, Applied DNA has proprietary means, which are the accountable of awaiting apparent applications, for abiogenetic apparel that access the expression, folding adeptness and compartmentalization of proteins that can be congenital into the accepted vaccine constructs if the after-effects acquired in beastly studies accreditation this consideration.

Continued Dr. Hayward, “Our patented and proprietary belvedere for the assembly of LinearDNA not alone empowers accelerated development and all-embracing production, but we accept it has the abeyant to crop an able vaccine with beneath risks than added currently activated DNA assembly platforms. As is archetypal for RNA viruses, coronaviruses adapt at accelerated ante that crave connected surveillance. We accept that one of the abounding allowances of PCR-produced LinearDNA is the acceleration at which a accepted vaccine can be revised to board mutational drift.”

Dr. Luigi Aurisicchio, CEO and CSO of Takis Biotech, stated: “Our aboriginal accord beneath the JDA on a pan blight vaccine that will anon access trials for the assay of accompaniment animals has already accurate the adeptness of PCR-produced LinearDNA to abet able allowed responses in beastly models. For the consecration of antibodies that can abrogate COVID-19, it is capital to use reliable, able technologies that can be bound acclimatized in the face of alive pathogens, and we accept that is the advantage that Applied DNA’s belvedere affords us over acceptable vaccine development and added avant-garde DNA-based vaccines. This all-around emergency requires a abrupt response.”

Under the agreement of the adapted JDA, Takis will use the scaled-up LinearDNA constructed genes produced by Applied DNA for anniversary of the four accepted vaccines to bathe mice, whose sera will be activated for the attendance of antibodies that bind to the antiseptic Fasten proteins. Those absolute candidates that bind to Fasten will be activated for their adeptness to abrogate COVID-19 by preventing uptake of the virus in beef in ability and in beastly models.

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The abeyant advantages airish by PCR-produced LinearDNA vaccines, as against to the annular DNA acquired from added acceptable plasmid sources, board the acceleration of production, the absence of antibiotics and their attrition genes, the abstention of the DNA, the artlessness of design, the able immunogenicity accepted in a above-mentioned LinearDNA vaccine, the absence of any bacterial contaminants and the actuality that the vaccine gene is able afterwards admittance into the patient’s genome.

Applied DNA and Takis accomplish bright that no bartering accomplice has been articular to booty the coronavirus vaccine to bazaar nor is there any adumbration that the Company’s applications to beforehand countermeasures would be accustomed by regulators.

About Takis Biotech.

Takis is a Biotech Aggregation created by a accumulation of scientists from Merck Assay Laboratories (MRL). The accumulation has added than 15 years of acquaintance and an accustomed clue almanac in biologic assay in Oncology and is accustomed for the apperception and accomplishing of a cardinal of avant-garde technologies. One of the capital assets of Takis is the ability in in vivo electro-gene-transfer, which can be acclimated for a array of clinically advantageous applications, from vaccine development to actual gene therapy. Takis activity board four Blight Vaccine candidates based on this technology. Takis is additionally actively complex in the bearing of humanized monoclonal antibodies for use in Oncology and Infectious Diseases.

Visit www.takisbiotech.it for added information.

About Applied DNA Sciences, Inc.

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Applied DNA is a provider of atomic technologies that accredit accumulation alternation security, anti-counterfeiting and anti-theft technology, artefact genotyping, affection and pre-clinical nucleic acid-based ameliorative biologic candidates.

Visit adnas.com for added information. Follow us on Twitter and LinkedIn. Join our commitment list. Common banal listed on NASDAQ beneath the attribute APDN.

LinearDNA™ is a brand of Applied DNA Sciences, Inc

Forward-Looking Statements

The statements fabricated by Applied DNA in this columnist absolution may be “forward-looking” in attributes aural the acceptation of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. Advanced statements call Applied DNA’s approaching plans, projections, strategies and expectations, and are based on assumptions and absorb a cardinal of risks and uncertainties, abounding of which are above the ascendancy of Applied DNA. Actual after-effects could alter materially from those projected due to the achievability of a abortion to accomplish appropriate acquittal on its outstanding anchored convertible addendum and consistent administration by noteholders of remedies on accessory which includes essentially all of Applied DNA’s assets, its history of net losses, bound banking resources, bound bazaar acceptance, the actuality that there has never been a bartering biologic artefact utilizing PCR-produced DNA technology accustomed for ameliorative use, the uncertainties inherent in assay and development, approaching analytic abstracts and analysis, including whether any of Applied DNA’s or its ally artefact candidates will beforehand added in the preclinical assay or analytic balloon process, including accepting approval from the U.S. Food and Biologic Administration or agnate adopted authoritative agencies to conduct analytic trials and whether and when, if at all, they will accept final approval from the U.S. FDA or agnate adopted authoritative agencies, and assorted added factors abundant from time to time in Applied DNA’s SEC letters and filings, including our Annual Address on Form 10-K filed on December 12, 2019 and our consecutive annual address on Form 10-Q filed on February 6, 2020, and added letters we book with the SEC, which are accessible at www.sec.gov. Applied DNA undertakes no obligation to amend about any advanced statements to reflect new information, contest or affairs afterwards the date hereof or to reflect the accident of hasty events, unless contrarily appropriate by law.

Web: www.adnas.com

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Twitter: @APDN

View antecedent adaptation on businesswire.com: https://www.businesswire.com/news/home/20200302005171/en/

SOURCE: Applied DNA Sciences Inc.

Investors: Sanjay M. Hurry LHA Investor Relations 212-838-3777 [email protected] Program contact: Brian Viscount Applied DNA 631-240-8877 [email protected]

Copyright Business Wire 2020

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